The Mechanism of Zoloft to Combat Depression

With nearly 30 million prescriptions written for Zoloft in a year, it is the leading antidepressant drug to treat major depression. Several studies conducted to analyze and compare the so-called “new generation” medicines to treat depression have determined that Zoloft is the most effective and best tolerated as the drug of choice. Perhaps it is important that we know how this drug acts in the body.

Pfizer manufactured Zoloft to respond to the millions of people calling for treatment to their mental illness. This drug can be given to treat a number of conditions affecting the brain. As with any other medicine, taking the prescription drug still needs precautions as overdose does happen to Zoloft users.

Zoloft, also known by its generic version sertraline hydrochloride, belongs to the type of drugs called selective serotonin reuptake inhibitors (SSRIs). SSRI’s work on a certain chemical in the brain called serotonin. It is among the neurotransmitters that get involve with the transfer of message from one nerve cell to another.

This neurotransmitter fills in the gaps between nerve cells in order to relay the signal from a cell to the next. After the signal has been passed on the first cell then immediately consumes the remaining serotonin the remains in the spaces between cells. This action is called “reuptake.”

By and large this mechanism goes on without any troubles. Yet, things don’t always go well, especially when serotonin levels go down where problems may happen which includes major depression and panic disorder. Zoloft helps maintain ample amount of serotonin between nerve cells by blocking the reuptake of serotonin from the spaces between cells.

Zoloft, as what studies and actual users have testified, works wonders in providing relief for major depression. Additionally, Obsessive-compulsive disorder (OCD), Panic disorder, Post-traumatic stress disorder (PTSD), Premenstrual dysphoric disorder (PMDD), Social anxiety disorder, otherwise known as social phobia can also be treated with this drug. It is important to note, however, that it may take a few days or weeks before the peak effect is achieved.

What makes Zoloft highly recommendable than other antidepressant drugs is that it has fewer and less severe side effects. However, recent human data revealing the risk of Zoloft birth defects make the drug contraindicated to pregnant women. As the evidences of this report continue to rise in number, it is imperative to ask your health care provider to change your medical treatment if you do not want your child to have a congenital anomaly.

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