Fosamax is arguably the most popular bone-strengthening drug prescribed for bone diseases like osteoporosis and osteitis deformans – Paget’s disease. A lot of reports, both good and bad, have been brought including the recently reviewed link between Fosamax and esophageal cancer. As Fosamax is already well-received by the public, Fosamax Plus D is often underrated, though it may have comparable efficacy with the former with its sister drug.
Fosamax Plus D is known generically as alendronate sodium and cholecalciferol. As a biphosphonate, alendronate works by altering the bone cycle particularly on the bone resorption process. Bone breakdown is reduced which apparently increases the density of the bone.
Cholecalciferol, on the other hand, is the form of vitamin D after it has been synthesized by the sunlight. It is later converted into the calcium-regulating hormone known as calcitriol. Calcitriol regulates the level of serum calcium by:
- Decreasing the calcium excretion to the urine by the kidney
- Increasing the absorption of calcium from the small intestine
- Increasing the release of calcium into the blood from bone
Fosamax Plus D won the approval of the Food and Drug Administration (FDA) as treatment for osteoporosis in menopausal women and also in men who are having low bone mineral density. But, patients suffering from diseases where there is excessive production of vitamin D, e.g. leukemia, giving this drug is contraindicated. Additionally, patients suffering from renal failure are not advised to take this drug.
Apparently, Fosamax Plus D has the same dosing instructions with Fosamax – that is the drug should be taken after rising up in the bed at least half an hour before the first food, drink or other medications. Administer the drug with a full glass of plain water only, not even mineral water, and remain standing or sitting upright for at least half an hour after drinking the medicine.
The side effects of Fosamax are also the same side effects you may experience with Fosamax Plus D mainly because both medication contain alendronate. In addition, there may be a need to check the level of vitamin D in your blood as this drug contains a week worth of recommended vitamin D intake and overdose of this vitamin may occur. This matter need to be talked with your physician.
Since this drug practically has the identical material with Fosamax, Fosamax Plus D may also bring about unfavorable effects such as atypical fracture of the thigh bone and osteonecrosis (tissue death) of the jawbone. Many users have filed a Fosamax lawsuit for this reason.
Tags: Health and Fitness